In research study that could result in a fundamental treatment of autism spectrum disorder, researchers have actually recognized the cell-specific molecular network of the developmental disability.
Researchers in South Korea have been successful in recognizing the cell-specific molecular network of autism spectrum disorder. It is anticipated to lay the foundation for dealing with autism spectrum condition. Published in the journal Molecular Psychiatry, the research was conducted by Professor Kim Min-siks group of researchers at the Department of New Biology, DGIST (Daegu Gyeongbuk Institute of Science and Technology).
Autism spectrum condition is a developmental disability that is understood to happen from early youth. It is a neuro-developmental condition defined by constant disability of social interaction and interaction-related behaviors leading to limited varieties of behavioral patterns, interests, and activities, along with repetitive habits.
Many autism spectrum condition clients have behavioral disorders, in some cases accompanied by other developmental impairments. Since there is presently no precise molecular medical diagnosis method, early medical diagnosis of autism spectrum condition is made at a fairly late period. Although there has been some success in enhancing signs with behavioral management treatment, there is an absence of reliable treatments at the molecular level.
Professor Kim Min-siks group utilized the Cntnap2 problem design, a spectral condition mouse model developed by Professor Lee Yong-Seoks team at Seoul National University College of Medicine to draw out prefrontal cortex tissue and performed mass spectrometry-based incorporated quantitative proteomic and metabolomic analysis. In addition, by comparing and analyzing this with previously reported big information of autism spectrum condition clients, the group verified that issues happen in networks such as metabolism and synapses in excitable nerve cells.
Professor Kim Min-sik of the Department of New Biology stated, “The multi-omics incorporated analysis technology established through this study has advanced the pathological understanding of autism spectrum condition and made it possible to find an integrated network ranging from molecular-level cell distinction induced by a particular autism gene to biometric information,” and included, “We are attempting to discover the core network of autism spectrum disorder and find treatment targets by carrying out an integrated analysis of numerous designs.”
Reference: “Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis” by Wooyoung Eric Jang, Ji Hwan Park, Gaeun Park, Geul Bang, Chan Hyun Na, Jin Young Kim, Kwang-Youl Kim, Kwang Pyo Kim, Chan Young Shin, Joon-Yong An, Yong-Seok Lee and Min-Sik Kim, 17 October 2022, Molecular Psychiatry.DOI: 10.1038/ s41380-022-01822-1.
This research was performed with assistance from the Brain Science Source Technology Development Project of the Ministry of Science and ICT.