Over 37 million Americans have diabetes, and 90-95% of that population are identified with type 2 diabetes. Way of life interventions, such as a healthy diet and a regular physical activity program, are techniques to manage diabetes. A new research study from a collaboration of private investigators at Brigham and Womens Hospital, an establishing member of the Mass General Brigham healthcare system, and Joslin Diabetes Center, part of Beth Israel Lahey Health, uses information from the Look AHEAD (Action for Health in Diabetes) research study, a randomized controlled trial that compared an extensive way of life intervention with diabetes assistance and education in patients diagnosed with type 2 diabetes and obese or obesity to track the advancement of cardiovascular disease over time. Their findings recommend patients with type 2 diabetes who were physically active in the afternoon had the largest improvements after one year in the trial. The teams results are published in Diabetes Care.
Physicians suggest that patients with diabetes participate in routine physical activity as an approach to manage their blood glucose levels. Elevated blood glucose levels can put individuals with type 2 diabetes at threat of heart disease, vision impairment, and kidney disease.
The group analyzed physical activity data from the 4th and very first years of the Look AHEAD study, which included data from over 2,400 individuals. Throughout the study, participants wore a waist accelerometry tape-recording device to measure physical activity.
The Brigham and Joslin group note that their examination has restrictions; for example, their study is observational and does not measure confounding aspects like sleep and dietary consumption.
In future studies, the team might test their findings experimentally to investigate the underlying systems that might explain why time of day of activity might influence blood glucose control. From this, the team may have the ability to offer particular exercise recommendations for patients.
” Timing does appear to matter,” stated co-corresponding author Roeland Middelbeek, MD, assistant private investigator at Joslin Diabetes Center. “Going forward, we might have more data and experimental evidence for patients to provide more tailored recommendations.”
Reference: “Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial” by Jingyi Qian, Qian Xiao, Michael P. Walkup, Mace Coday, Melissa L. Erickson, Jessica Unick, John M. Jakicic, Kun Hu, Frank A.J.L. Scheer, Roeland J.W. Middelbeek and Look AHEAD Research Group, 25 May 2023, Diabetes Care.DOI: 10.2337/ dc22-2413.
This study was funded by the National Heart, Lung, and Blood Institute (K99-HL-148500, R01-HL140574), National Institute on Aging (RF1AG059867 and RF1AG064312), and National Institute of Diabetes and Digestive and Kidney Diseases (K23-DK114550). The Look AHEAD research study was supported by the Department of Health and Human Services through the following cooperative arrangements from the National Institutes of Health, NIDDK: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. Extra financing was provided by the National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Center on Minority Health and Health Disparities, National Institutes of Health Office of Research on Womens Health, and the Centers for Disease Control and Prevention. This research study was supported in part by the NIDDK Intramural Research Program. Extra assistance was gotten from the Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719), the Massachusetts General Hospital Mallinckrodt General Clinical Research Center and the Massachusetts Institute of Technology General Clinical Research Center (M01RR01066), the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520), the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140), the University of Pittsburgh General Clinical Research Center (M01RR000056), the Clinical Translational Research Center moneyed by the Clinical & & Translational Science Award (UL1RR024153) and National Institutes of Health NIDDK grant (DK 046204), the VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs, and the Frederic C. Bartter General Clinical Research Center (M01RR01346). The Indian Health Service (IHS) offered personnel, medical oversight, and use of facilities.
Disclosures: The following organizations have actually committed to make significant contributions to Look AHEAD: Federal Express, Health Management Resources, Johnson & & Johnson, LifeScan Inc., Optifast-Novartis Nutrition, Roche Pharmaceuticals, Ross Product Division of Abbott Laboratories, SlimFast Foods Company, and Unilever.
J.M.J. is on the clinical board of advisers for Wondr Health, Inc. F.A.J.L.S. serves on the Sleep Research Society Board of Directors and has actually received seeking advice from costs from the University of Alabama at Birmingham. R.J.W.M. has actually gotten research funding from Novo Nordisk unassociated to this work.
A study by researchers from Brigham and Womens Hospital and Joslin Diabetes Center suggests that afternoon physical activity can substantially enhance blood glucose control in type 2 diabetes patients. Utilizing data from the Look AHEAD study, the team discovered that those most active in the afternoons had the best blood glucose reduction and were more than likely to stop diabetes medications.
In an analysis of the Look AHEAD study, researchers from the Brigham and Joslin Diabetes Center found that individuals who were physically active in the afternoon had greater decreases in blood sugar level than those who were most active at other times of day.
Over 37 million Americans have diabetes, and 90-95% of that population are detected with type 2 diabetes. Way of life interventions, such as a healthy diet and a regular physical activity program, are methods to manage diabetes. A new research study from a collaboration of detectives at Brigham and Womens Hospital, a founding member of the Mass General Brigham healthcare system, and Joslin Diabetes Center, part of Beth Israel Lahey Health, uses information from the Look AHEAD (Action for Health in Diabetes) research study, a randomized regulated trial that compared an extensive lifestyle intervention with diabetes assistance and education in patients diagnosed with type 2 diabetes and overweight or obesity to track the development of cardiovascular disease over time.
” In this study, we revealed that grownups with type 2 diabetes had the biggest improvement in glucose control when they were most active in the afternoon,” said co-corresponding author Jingyi Qian, PhD, from the Division of Sleep and Circadian Disorders at the Brigham. “Weve known that physical activity is beneficial, but what our research study includes is a brand-new understanding that timing of activity may be necessary too.”
