The lower temperature in RPA increases the danger of nonspecific amplification, so Merkx sought a delicate service.”The charm of bioluminescence is its simplicity,” said Merkx. The group checked this platform on COVID-19 samples and detected SARS-CoV-2 RNA within 30 minutes.
The lower temperature in RPA increases the threat of nonspecific amplification, so Merkx looked for a sensitive service.”The beauty of bioluminescence is its simplicity,” said Merkx. The group split luciferase, an enzyme that produces bioluminescence, in between two dCas9 proteins. The group tested this platform on COVID-19 samples and spotted SARS-CoV-2 RNA within 30 minutes.