A recent study by a global group, using ingenious fluorescence microscopy strategies, has actually successfully visualized the 3D structure of the ASC speck, solving enduring debates and marking a significant improvement in the understanding of inflammasome biology. An elegant analysis of the microscopy images of a large number of ASC specks also suggests that as the ASC protein collects within the speck, the speck scarcely grows at all, however mostly becomes denser.” Our results solve the existing debates in relation to the structure of the ASC speck and are an essential action on the road to the total visualization of the inflammasome in cells,” says Dr. Ivo Glück, first author of the new study.
A current research study by a global team, using innovative fluorescence microscopy methods, has actually successfully envisioned the 3D structure of the ASC speck, solving enduring debates and marking a substantial advancement in the understanding of inflammasome biology. The ASC speck is a central part of the NLRP3 inflammasome. A classy analysis of the microscopy images of a large number of ASC specks also shows that as the ASC protein builds up within the speck, the speck hardly grows at all, however mainly becomes denser.” Our outcomes solve the existing debates in relation to the structure of the ASC speck and are an important step on the road to the complete visualization of the inflammasome in cells,” states Dr. Ivo Glück, very first author of the new study.