November 22, 2024

Challenging Established Models – How a Worm Is Helping Scientists Unravel One of Science’s Great, Tantalizing Mysteries

This implies that researchers have compiled a comprehensive diagram, or “map,” of all its synapses and neurons– the locations where nerve cells physically interact and link with other neurons. Instead of the more conventional system of utilizing an electrode to deliver a current into a neuron and thus promote a response, the optogenetic strategy includes utilizing light-sensitive proteins from certain organisms and implanting those cells in another organism so that researchers can control an organisms habits or responses using light signals.Similarly, other proteins can be used to light up and report when one neuron signals to another.”For this experiment, we went one neuron at a time through the entire brain, perturbing each nerve cell or activating and then enjoying the whole network respond,” stated Leifer.”This was a method that had actually never ever been done in the past at the scale of a whole brain,” added Leifer.In all, Leifer and his team carried out almost 10,000 stimulus events by determining over 23,000 pairs of neurons and their responses, a job that took 7 years from conception to completion.Challenging Established Models and Introducing New InsightsThe research carried out by Leifer and his team is therefore far the most thorough description of how signals stream through the brain. Wireless signaling is a kind of signaling by which a neuron launches molecules, called neuropeptides, into the extracellular area, or “extracellular milieu,” in between nerve cells.

Instead of the more standard system of using an electrode to provide a current into a nerve cell and thereby promote a reaction, the optogenetic technique involves utilizing light-sensitive proteins from particular organisms and implanting those cells in another organism so that researchers can manage an organisms behavior or reactions utilizing light signals.Similarly, other proteins can be used to light up and report when one nerve cell signals to another.”For this experiment, we went one nerve cell at a time through the whole brain, disturbing each nerve cell or activating and then viewing the entire network respond,” said Leifer. Wireless signaling is a kind of signaling by which a neuron launches molecules, called neuropeptides, into the extracellular area, or “extracellular milieu,” between neurons.