” The idea that we might reverse aging is something that was long considered science fiction, but these findings do permit us to comprehend a lot more about the aging procedure,” states Riekelt Houtkooper, Professor at the lab Genetic Metabolic Diseases of Amsterdam UMC. By understanding more about the aging process, we can also look into new ways of intervening,” says Georges Janssens, very first author of the paper and assistant professor at Amsterdam UMC.Research on Age-Related DiseasesIn recent years, lab research has actually shown that we may be able to combat age-related diseases by intervening in the basic procedures that lead to aging. We prepare to perform follow-up studies to better comprehend how BMPs contribute to aging, what are the effects of BMP accumulation on the aging procedure, and whether this can only be influenced by workout or are the other methods to impact BMPs levels,” concludes Houtkooper.Reference: “A conserved complex lipid signature marks human muscle aging and responds to short-term workout” by Georges E. Janssens, Marte Molenaars, Katharina Herzog, Lotte Grevendonk, Carlijn M. E. Remie, Martin A. T. Vervaart, Hyung L. Elfrink, Eric J. M. Wever, Bauke V. Schomakers, Simone W. Denis, Hans R. Waterham, Mia L. Pras-Raves, Michel van Weeghel, Antoine H. C. van Kampen, Alessandra Tammaro, Loes M. Butter, Sanne van der Rijt, Sandrine Florquin, Aldo Jongejan, Perry D. Moerland, Joris Hoeks, Patrick Schrauwen, Frédéric M. Vaz and Riekelt H. Houtkooper, 12 April 2024, Nature Aging.DOI: 10.1038/ s43587-024-00595-2.
Researchers have actually found that certain fats build up in tissues with age but can be lowered through routine exercise. This finding, which sheds brand-new light on the biological processes of aging, was stemmed from research studies performed on both mice and people, emphasizing the capacity for brand-new aging interventions.Scientists have actually discovered that a particular type of fat builds up in tissues as they age, which workout can reverse this procedure. A group from Amsterdam UMC, in cooperation with scientists from Maastricht UMC+, studied tissue from both mice and humans before and after workout to reach this conclusion.The outcomes were recently published in the journal Nature Aging.” The idea that we could reverse aging is something that was long considered science fiction, however these findings do permit us to comprehend a lot more about the aging process,” states Riekelt Houtkooper, Professor at the lab Genetic Metabolic Diseases of Amsterdam UMC. “Everyone says that its just part of getting older, but this does not in fact have to be true. By understanding more about the aging process, we can likewise check out new ways of intervening,” states Georges Janssens, first author of the paper and assistant teacher at Amsterdam UMC.Research on Age-Related DiseasesIn recent years, laboratory research study has revealed that we might be able to combat age-related illness by intervening in the fundamental procedures that result in aging. Although science has actually increasingly drawn up how metabolism modifications during aging, large parts remained uncharted. “We wanted to include a new chapter to the atlas. Lipids are a fundamental part of our diet plan, and vital for the performance of our body cells. Particular lipids comprise the membrane of cells, which guarantees that the inside and outdoors remain different,” states Houtkooper.In order to add this new chapter, the research group investigated how the composition of fats changes in mice. They looked at 10 various tissues, consisting of muscles, kidneys, liver, and heart. It was observed that a person type of lipid, the bis( monoacylglycero) phosphates (or BMPs), were elevated in all tissues from the older animals. Recommending a build-up of these lipids during aging. They then investigated whether this likewise occurs in humans. It was not possible to get as lots of various tissues, the accumulation of BMP was likewise noticeable in muscle biopsies of older people. Finally, they then finished more muscle biopsies from individuals before and after a healthy intervention that included one hour of exercise a day and saw the level of BMPs decreased in the active participants.” These outcomes are a crucial brand-new action for our understanding of the aging procedure, but they are definitely not the last answer. We prepare to carry out follow-up research studies to better understand how BMPs contribute to aging, what are the consequences of BMP accumulation on the aging process, and whether this can just be affected by exercise or are the other ways to impact BMPs levels,” concludes Houtkooper.Reference: “A saved complex lipid signature marks human muscle aging and responds to short-term workout” by Georges E. Janssens, Marte Molenaars, Katharina Herzog, Lotte Grevendonk, Carlijn M. E. Remie, Martin A. T. Vervaart, Hyung L. Elfrink, Eric J. M. Wever, Bauke V. Schomakers, Simone W. Denis, Hans R. Waterham, Mia L. Pras-Raves, Michel van Weeghel, Antoine H. C. van Kampen, Alessandra Tammaro, Loes M. Butter, Sanne van der Rijt, Sandrine Florquin, Aldo Jongejan, Perry D. Moerland, Joris Hoeks, Patrick Schrauwen, Frédéric M. Vaz and Riekelt H. Houtkooper, 12 April 2024, Nature Aging.DOI: 10.1038/ s43587-024-00595-2.
