The findings lead to improved polygenic risk ratings, which will better forecast blood pressure and danger for hypertension.Researchers led by Queen Mary University of London and supported by the National Institute for Health and Care Research (NIHR) have actually discovered over a hundred brand-new regions of the human genome, likewise known as genomic loci, that appear to affect an individuals blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly intricate quality influenced by thousands of various hereditary variants.Extensive Study on Blood Pressure GeneticsThe research study, published in Nature Genetics, is one of the largest such genomic research studies of blood pressure to date, including data from over 1 million individuals and laying the groundwork for scientists to much better understand how blood pressure is regulated.To comprehend the genetics of blood pressure, the scientists combined four large datasets from genome-wide association studies (GWAS) of blood pressure and high blood pressure. When blood pressure is regularly too high, it can harm the heart and blood vessels throughout the body, increasing a persons danger for heart illness, kidney illness, stroke, and other conditions.Reference: “Genome-wide analysis in over 1 million people of European ancestry yields improved polygenic danger scores for blood pressure characteristics” by Patricia B. Munroe, Helen R. Warren, et al. 30 April 2024, Nature Genetics.DOI: 10.1038/ s41588-024-01714-wThe research study combined previously released genetic information from the UK Biobank, a massive biomedical database and research resource containing genetic and health details from half a million UK individuals (N ~ 450,000 people); the International Consortium for Blood Pressure (N ~ 300,000 people integrated from 77 different mate studies); and the U.S. Department of Veterans Affairs Million Veteran Program (N ~ 220,000 individuals), with new data from Vanderbilt University Medical Centers biorepository, BioVU (N ~ 50,000 individuals).
The findings lead to improved polygenic danger ratings, which will much better predict blood pressure and danger for hypertension.Researchers led by Queen Mary University of London and supported by the National Institute for Health and Care Research (NIHR) have discovered over a hundred new regions of the human genome, also understood as genomic loci, that appear to affect an individuals blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is an extremely complex characteristic influenced by thousands of different hereditary variants.Extensive Study on Blood Pressure GeneticsThe research study, published in Nature Genetics, is one of the biggest such genomic research studies of blood pressure to date, consisting of data from over 1 million people and laying the groundwork for researchers to much better understand how blood pressure is regulated.To understand the genes of blood pressure, the scientists combined four big datasets from genome-wide association studies (GWAS) of blood pressure and hypertension. When blood pressure is consistently too high, it can damage the heart and blood vessels throughout the body, increasing an individuals risk for heart illness, kidney illness, stroke, and other conditions.Reference: “Genome-wide analysis in over 1 million individuals of European origins yields improved polygenic danger ratings for blood pressure characteristics” by Patricia B. Munroe, Helen R. Warren, et al. 30 April 2024, Nature Genetics.DOI: 10.1038/ s41588-024-01714-wThe research study combined formerly published hereditary data from the UK Biobank, a massive biomedical database and research study resource including genetic and health information from half a million UK participants (N ~ 450,000 individuals); the International Consortium for Blood Pressure (N ~ 300,000 people combined from 77 different mate studies); and the U.S. Department of Veterans Affairs Million Veteran Program (N ~ 220,000 people), with new information from Vanderbilt University Medical Centers biorepository, BioVU (N ~ 50,000 individuals).
