Utilizing artificial biology, Gabriel Kwong, a biomedical engineer at Georgia Institute of Technology and Emory University, has actually developed an innovation to manage T cell therapies with heat and make cancer cells more sensitive to chemotherapy. The researchers administered gold nanoparticles, which passively build up in growths, through IV injection into mice with hind limb growths that had received the crafted CAR T cells. They irradiated the growths with near-infrared light to raise the temperature.Compared with mice that got only heat treatment or CAR T cells, the tumors in mice that got heat treatment and the engineered CART cells diminished quicker, Kwong and his team reported in Nature Biomedical Engineering.
Using artificial biology, Gabriel Kwong, a biomedical engineer at Georgia Institute of Technology and Emory University, has established a technology to control T cell treatments with heat and make cancer cells more sensitive to chemotherapy.”Ali Zamat (left) and Gabe Kwong (ideal) combine heat treatment with CAR T cell treatment to diminish tumors in mice.Jerry Grillo, Georgia TechAs an engineer, Kwong has an unique approach. The scientists administered gold nanoparticles, which passively accumulate in growths, via IV injection into mice with hind limb tumors that had received the engineered CAR T cells. They irradiated the tumors with near-infrared light to raise the temperature.Compared with mice that received only heat treatment or CAR T cells, the growths in mice that got heat treatment and the engineered CART cells shrunk quicker, Kwong and his group reported in Nature Biomedical Engineering.