December 5, 2023

Elevated Resting Heart Rate Linked to Increased Risk of Dementia

Having a raised resting heart rate in aging may be an independent danger aspect of dementia, according to a study at Karolinska Institutet in Sweden released in the journal Alzheimers & & Dementia: The Journal of the Alzheimers Association. Considering that resting heart rate is simple to determine and can be reduced through exercise or medical treatment, the researchers think that it might assist to recognize people with greater dementia threat for early intervention.
The number of individuals dealing with dementia is anticipated to increase to 139 million globally by 2050, from 55 million in 2020, according to the company Alzheimers Disease International. Presently, there is no treatment for dementia, however growing proof recommends that keeping a healthy lifestyle and cardiovascular health might assist postpone the start of dementia and ease signs.

The study, which followed the participants for up to 12 years, showed that individuals with a resting heart rate of 80 beats per minute or higher on average had 55 percent higher risk of dementia than those with a heart rate of 60-69 beats per minute. The association stayed significant after changing for possible confounders such as numerous cardiovascular diseases. Still, the scientists caution that the result may have been impacted by unnoticed cardiovascular occasions and the fact that more individuals with cardiovascular disease passed away throughout the follow-up period and therefore didnt have time to establish dementia.

Yume Imahori, postdoc scientist at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet. Credit: Stefan Zimmerman
In this study, the scientists examined if resting heart rate in 2,147 individuals 60 years old or older and living in Stockholm might be connected to dementia and cognitive decline independent of other known threat factors, such as cardiovascular illness.
The research study, which followed the participants for approximately 12 years, showed that individuals with a resting heart rate of 80 beats per minute or higher on average had 55 percent higher risk of dementia than those with a heart rate of 60-69 beats per minute. The association stayed substantial after adjusting for prospective confounders such as various heart diseases. Still, the scientists warn that the result may have been affected by unnoticed cardiovascular events and the reality that more individuals with heart disease passed away during the follow-up duration and therefore didnt have time to develop dementia.
The research study can not establish a causal relationship, but the scientists provide a number of plausible explanations for the association, consisting of the effect of underlying heart diseases and cardiovascular threat factors, stiffened arteries, and imbalance in between parasympathetic and understanding nerve activities.
” We believe it would be valuable to explore if resting heart rate might recognize patients with high dementia danger,” says the studys leading author Yume Imahori, a scientist at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet. “If we follow such patients cognitive function thoroughly and intervene early, the beginning of dementia might be delayed, which can have a considerable effect on their lifestyle.”
The study was led by senior lecturer Dr. Chengxuan Qiu and the information was stemmed from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K).
The research study was moneyed by the Swedish Ministry of Health and Social Affairs, the Swedish Research Council, the Swedish Research Council for Health, Working Life and Welfare, the Swedish Foundation for International Cooperation in Research and Higher Education, Karolinska Institutet, and the European Union. See the scientific post for declarations of interest.
Reference: “Association of resting heart rate with cognitive decline and dementia in older grownups: a population-based accomplice research study” by Yume Imahori, Davide L Vetrano, Xin Xia, Giulia Grande, Petter Ljungman, Laura Fratiglioni, Chengxuan Qiu, 3 December 2021, Alzheimers & & Dementia: The Journal of the Alzheimers Association.DOI: 10.1002/ alz.12495.