June 10, 2023

Severe COVID-19 Neurological Symptoms Highlight the Need for Rigorous Research

Acute COVID-19 infection can in some cases result in long-lasting effects, that have actually collectively been termed “Long Covid,” and can consist of a wide range of symptoms in the brain and worried system that range from a loss of taste and smell, impaired concentration, fatigue, discomfort, sleep conditions, autonomic conditions and/or headache to mental effects such as depression or psychosis.
Drs. Nath and Spudich outline the existing scientific understanding of the possible body responses to intense COVID-19 infection and how those reactions could cause Long Covid signs. They also draw parallels in between the symptoms experienced by individuals with Long Covid to those coping with myalgic encephalomyelitis/chronic tiredness syndrome (ME/CFS) or post-Lyme disease, which recommends there might be common danger elements involved.
Lastly, owing to the considerable variability in symptoms from person to individual and the reality that lots of individuals with Long Covid were healthy prior to a reasonably mild COVID-19 infection, the authors highlight the immediate requirement for considerable research efforts into determining the full degree of Long Covid problems and their causes. This sort of research study, which would include the careful study of people with Long Covid classified by their particular signs, is vital to the advancement of healing and diagnostic tools to deal with and determine what is ending up being an ever-increasing public health issue. The NIH RECOVER COVID effort is an ambitious research program to reach these goals.
Reference: “Nervous system repercussions of COVID-19” by Serena Spudich and Avindra Nath, 20 January 2022, Science.DOI: 10.1126/ science.abm2052.
NINDS is the nations leading funder of research study on the brain and nerve system. The mission of NINDS is to look for essential knowledge about the brain and nervous system and to use that knowledge to decrease the burden of neurological disease.
About the National Institutes of Health (NIH): NIH, the nations medical research study firm, consists of 27 Institutes and Centers and is an element of the U.S. Department of Health and Human Services. NIH is the primary federal agency performing and supporting basic, clinical, and translational medical research study, and is examining the causes, treatments, and remedies for both common and unusual illness.

SARS-CoV-2 was initially recognized as a respiratory infection, however it can affect the entire body, consisting of the nerve system. In a brand-new Viewpoint released in Science, Avindra Nath, M.D., scientific director of the National Institutes of Healths National Institute of Neurological Disorders and Stroke (NINDS), and Serena Spudich, M.D., Yale School of Medicine, New Haven, Connecticut, emphasize what is presently understood about the effects of SARS-CoV-2 on the brain, the value of increased research study into the underlying causes of Long Covid and possible methods to treat its symptoms.
Neurological symptoms that have been reported with intense COVID-19 consist of loss of taste and smell, headaches, stroke, brain, and delirium inflammation. There does not seem to be substantial infection of brain cells by the infection, but the neurological results might be brought on by immune activation, neuroinflammation, and damage to brain blood vessels.