June 19, 2024

Higher Antioxidant Levels Linked to Lower Alzheimer’s Disease, Dementia Risk

According to new research, individuals with greater levels of anti-oxidants in their blood may be less most likely to establish dementia.
People with greater levels of anti-oxidants in their blood may be less most likely to establish dementia, according to research study released in the May 4, 2022, online concern of Neurology, the medical journal of the American Academy of Neurology.
The study found that individuals with the greatest levels of the anti-oxidants lutein and zeaxanthin and beta-cryptoxanthin in their blood were less most likely to develop dementia decades behind people with lower levels of the antioxidants. Lutein and zeaxanthin are found in leafy, green vegetables such as spinach, kale, broccoli, summertime squash, and peas. Beta-cryptoxanthin is found in fruits such as oranges, mangoes, papaya, peaches, tangerines, and persimmons.
” Extending peoples cognitive performance is a crucial public health obstacle,” said study author May A. Beydoun, PhD, MPH, of the National Institutes of Healths National Institute on Aging in Baltimore, Maryland. “Antioxidants may assist protect the brain from oxidative stress, which can trigger cell damage. Further research studies are required to evaluate whether adding these antioxidants can assist secure the brain from dementia.”

The study found that people with the highest levels of the anti-oxidants lutein and zeaxanthin and beta-cryptoxanthin in their blood were less likely to develop dementia years later on than individuals with lower levels of the anti-oxidants. They had a physical examination, interview, and blood tests for antioxidant levels at the start of the research study. The individuals were divided into 3 groups based on their levels of anti-oxidants in the blood.

The research study involved 7,283 people who were at least 45 years of ages at the start of the research study. They had a physical examination, interview, and blood tests for antioxidant levels at the start of the study. They were then followed for approximately 16 years to see who established dementia.
The participants were divided into three groups based upon their levels of anti-oxidants in the blood. People with the highest amounts of lutein and zeaxanthin were less likely to develop dementia than those with lower levels. Every basic deviation boost in lutein and zeaxanthin levels, around 15.4 micrograms/deciliter, was connected with a 7% decline in risk of dementia. For beta-cryptoxanthin, every basic deviation increase in levels, approximately 8.6 micrograms/deciliter, was related to a 14% reduced threat of dementia.
” Its crucial to note that the impact of these antioxidants on the danger of dementia was decreased rather when we took into consideration other elements such as education, earnings, and exercise, so its possible that those aspects might assist discuss the relationship in between antioxidant levels and dementia,” Beydoun stated.
A limitation of the study is that antioxidant levels were based upon one measurement of blood levels and may not show peoples levels over their lifetime.
Reference: “Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults” by May A. Beydoun, Hind A Beydoun, Marie T. Fanelli-Kuczmarski, Jordan Weiss, Sharmin Hossain, Jose Atilio Canas, View ORCID ProfileMichele Kim Evans and Alan B. Zonderman, 4 May 2022, Neurology.DOI: 10.1212/ WNL.0000000000200289.
The research study was supported by the National Institute on Aging, part of the National Institutes of Health.