June 19, 2024

New Evidence for Alternate Origins of Alzheimer’s Disease Plaques

Now, new research findings point in a new direction.A breakdown in how brain cells rid themselves of waste precedes the accumulation of debris-filled plaques known to take place in Alzheimers disease, a new research study in mice shows.The field argued for years that such plaques, containing the protein amyloid beta, built up outside of cells as an important very first action towards the brain damage observed in Alzheimers illness. Lysosomes are also key, researchers note, to breaking down and disposing of a cells own parts when the cell naturally dies.As part of the research study, scientists tracked decreasing acid activity inside intact mouse cell lysosomes as the cells became injured in the illness. Credit: Courtesy of Springer-Nature Publishing”This new evidence alters our basic understanding of how Alzheimers disease advances; it also discusses why so numerous experimental therapies developed to remove amyloid plaques have stopped working to stop illness development, since the brain cells are already maimed prior to the plaques fully form outside the cell,” says research study senior investigator Ralph Nixon, MD, PhD.

Now, brand-new research study findings point in a brand-new direction.A breakdown in how brain cells rid themselves of waste precedes the buildup of debris-filled plaques known to occur in Alzheimers illness, a new research study in mice shows.The field argued for years that such plaques, consisting of the protein amyloid beta, constructed up outside of cells as a crucial first step towards the brain damage observed in Alzheimers disease. Lysosomes are also key, scientists note, to breaking down and disposing of a cells own parts when the cell naturally dies.As part of the study, scientists tracked reducing acid activity inside undamaged mouse cell lysosomes as the cells ended up being injured in the disease. Credit: Courtesy of Springer-Nature Publishing”This new evidence changes our essential understanding of how Alzheimers disease progresses; it also describes why so many experimental therapies developed to get rid of amyloid plaques have failed to stop illness development, because the brain cells are already maimed before the plaques totally form outside the cell,” says study senior detective Ralph Nixon, MD, PhD.