June 10, 2023

Caffeine Metabolite May Slow Progression of Nearsightedness in Children

According to a brand-new study, a caffeine metabolite might slow the development of short-sightedness (myopia) in kids.
If proved efficient in scientific trials, 7-MX might be an important future treatment.
A metabolite of caffeine, called 7-MX, may slow the progression of nearsightedness, also referred to as myopia, in kids. This is according to observational research released on August 22, 2022, in the British Journal of Ophthalmology.
According to the scientists, 7-MX could end up being a valuable treatment for a condition for which present choices are somewhat restricted if it is shown safe and effective in big clinical trials.
Myopia occurs when the eye grows too long, extending and thinning it. This frequently begins at the age of 6-7, advancing till the age of 16-20..

In addition to causing nearsightedness, myopia is associated with an increased threat of numerous conditions that affect vision and eye health, including macular degeneration, glaucoma, cataracts, and retinal detachment.
Initial research shows that the caffeine metabolite 7-methylxanthine, or 7-MX for short, inhibits excessive lengthening of the eye (axial elongation).
7-MX has been used to treat youth myopia in Denmark considering that 2009. But previously it has actually not been totally assessed in long-lasting research studies, and the investigators wished to learn how quickly myopia advances in children taking 7-MX.
The scientists reviewed the medical records of 711 kids (356 women and 355 kids) dealt with for myopia between June 2000 and January 2021 at one eye center in Denmark.
Comprehensive eye tests, consisting of measurement of axial length, were performed on the kids. 624 (88%) of the children took 7-MX tablets up to 1200 mg everyday (typical 470 mg) while 87 didnt, for various factors.
Their average age was 11 (variety 7-15) when they began treatment, and their eye length and degree of myopia were tracked for an average of 3 1/2 years (range 11 months– 9 years).
Diopters (D) are the units of measurement used to assess the level of eye function: the average degree of refractive mistake (near-sight) to start with was − 2.43 D, which increased by approximately 1.34 D throughout the monitoring period. -3.00 D is considered as reasonably severe myopia; -6 D or more is considered as severe myopia.
The average axial length was 24.4 mm, to start with, increasing by approximately 0.21 mm/year.
Treatment with 7-MX was associated with a slower rate of intensifying myopia and axial elongation, with higher doses relatively more reliable..
Based on these information, the researchers approximated that for a common 7-year-old with a refractive error of − 2.53 D to begin with, that kids myopia would increase by − 3.49 D over the next 6 years without treatment..
With a daily dosage of 1000 mg of 7-MX, that same kids myopia would increase by − 2.65 D over the next 6 years.
Likewise, without treatment, axial length would increase by 1.80 mm over 6 the next years, whereas it would only increase by 1.63 mm on a day-to-day dosage of 1000 mg.
According to the scientists estimations, typically, for an 11-year-old taking 1000 mg 7-MX daily that kids myopia would increase by − 1.43 D over the next 6 years, compared with − 2.27 D without treatment. And axial length would increase by 0.84 mm compared with 1.01 mm without treatment..
None of the kids taking 7-MX reported any negative effects during the monitoring duration.
According to the scientists, the findings echo those of speculative studies. However, they acknowledge that their study is observational, and they were not able to represent possibly influential factors, such as genetic elements, ethnic culture, time invested outdoors, and time invested in near work. Their findings can not, therefore, establish causality.
” The concern of causality and the size of a possible treatment effect can only be identified through a randomized trial,” they compose.
They conclude: “Existing myopia control intervention approaches are not fully effective in preventing children from progressing to high myopia, and 7-MX might become an important supplement if causality and effectiveness can be validated in future randomized regulated trials.”.
Reference: “Oral administration of caffeine metabolite 7-methylxanthine is associated with slowed myopia progression in Danish children” by Klaus Trier, Dongmei Cui, Søren Ribel-Madsen and Jeremy Guggenheim, 22 August 2022, British Journal of Ophthalmology.DOI: 10.1136/ bjo-2021-320920.