The researchers evaluated whether Rhodiola rosea could enhance glucose homeostasis using a genetically engineered mouse model that develops obesity, insulin resistance, and high blood glucose, equivalent to advanced human type 2 diabetes. Age-matched male and female mouse cohorts were arbitrarily assigned to either the control group, which got water, or the experimental group, who were administered Rhodiola rosea extract.
” Our findings recommend that Rhodiola rosea might be advantageous for dealing with type 2 diabetes, acting through modifications in the microbiome that result in increased gut barrier integrity and reduced translocation of inflammatory molecules into the blood flow,” Jafari said. “Gut barrier integrity influences body weight and insulin action, and this botanical product might improve the responses of liver and muscle tissues to the insulin produced by the pancreas.”
The groups next steps are to carry out a bigger follow-up research study in a different mouse design of obesity-induced diabetes to verify these findings and to examine the molecular systems involved. Ultimately, Jafari hopes to carry out Rhodiola rosea clinical trials in clients with type 2 diabetes.
” Our research study presents a strong case for the importance of conducting high-quality pre-clinical studies based on sound approaches to evaluate the effectiveness of standardized plant extracts. We have set the stage for human medical research studies, with the supreme goal of enhancing health results for type 2 diabetes clients,” Jafari stated.
Referral: “The impact of Rhodiola rosea on biomarkers of diabetes, swelling, and microbiota in a leptin receptor-knockout mouse model” by Mahtab Jafari, Jasmin Grace Juanson Arabit, Robert Courville, Dara Kiani, John M. Chaston, Cindy Duy Nguyen, Nilamani Jena, Zhong-Ying Liu, Prasanthi Tata, and Richard A. Van Etten, 22 June 2022, Scientific Reports.DOI: 10.1038/ s41598-022-14241-7.
The study was moneyed by the UCI School of Medicine-Pharmaceutical Sciences Collaborative Research Funds and Mr. and Mrs. John P. and Lois C. Wareham.
” The occurrence of type 2 diabetes and the associated health expenses have increased gradually in recent years. Human beings have utilized plants and natural products for thousands of years to treat diseases, and our research study reveals Rhodiola rosea is a great candidate for further investigation,” said matching author Dr. Mahtab Jafari, UCI teacher of pharmaceutical sciences. “Current treatment suggestions consist of way of life changes as well as intravenous and oral medications.
Extract from Rhodiola rosea roots could be helpful for dealing with diabetes.
Rhodiola rosea root could help manage type 2 diabetes, according to a University of California, Irvine study.
An extract from the roots of the Rhodiola rosea plant has been discovered to reveal guarantee as a safe and effective non-pharmaceutical alternative to assist control type 2 diabetes, according to a team of scientists led by the University of California, Irvine.
According to a research study just recently released in Scientific Reports, Rhodiola rosea lowered the number of inflammatory biomarkers and enhanced insulin reaction in a mouse design of type 2 diabetes. It also decreased fasting blood glucose levels and modified the structure of bacteria in the gastrointestinal tract.
” The occurrence of type 2 diabetes and the associated health costs have actually increased steadily in current decades. Human beings have actually used plants and natural products for countless years to treat diseases, and our study shows Rhodiola rosea is a great candidate for further examination,” said matching author Dr. Mahtab Jafari, UCI teacher of pharmaceutical sciences. “Current treatment suggestions consist of lifestyle modifications as well as oral and intravenous medications. Nevertheless, these drugs have considerable constraints or negative effects, increasing the need for brand-new therapeutic interventions.”