” The study revealed that cutting protein intake to 0.8 g per kg of body weight was adequate to accomplish almost the same medical outcomes as restricting calories, however without the need to decrease calorie consumption. The outcomes recommend that protein restriction may be one of the crucial factors leading to the known advantages of dietary restriction. Protein limitation dieting may for that reason be a more appealing nutritional technique and much easier to follow for individuals with metabolic syndrome,” said Rafael Ferraz-Bannitz, very first author of the post and presently a postdoctoral researcher at the Joslin Diabetes Center in Harvard Medical School in the United States.
The research study included twenty-one different patients with metabolic syndrome. They were provided either a calorie-restricted or protein-restricted diet plan
According to new research, protein restriction works in combating weight problems and diabetes.
According to a research study comparing the results of protein and calorie limitation diet plans in humans, reducing protein usage may assist manage metabolic syndrome and a few of its primary symptoms, such as weight problems, diabetes, and hypertension (high blood pressure). The research studys findings were just recently published in the journal Nutrients.
The term “metabolic syndrome” refers to a group of diseases, including hypertension, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels, that increase the threat of diabetes, heart disease, and stroke.
” The research study revealed that cutting protein consumption to 0.8 g per kg of body weight was enough to attain nearly the very same medical outcomes as limiting calories, however without the requirement to decrease calorie intake. The results suggest that protein restriction may be one of the crucial aspects resulting in the known benefits of dietary constraint. Protein limitation dieting might therefore be a more attractive dietary technique and simpler to follow for individuals with metabolic syndrome,” stated Rafael Ferraz-Bannitz, first author of the short article and currently a postdoctoral researcher at the Joslin Diabetes Center in Harvard Medical School in the United States.
The research study did not investigate the molecular systems that could describe the advantageous results of protein constraint diets, but the scientists believe low protein consumption set off a modification in the metabolic process or improved the organisms energy management by leading it to burn fat in order to produce energy for cells. “Studies in animal models have actually shown the involvement of such pathways in the impacts of both protein and calorie restriction, both of which lead to fat loss.”
Controlled diet plan.
The research study involved 21 people with metabolic syndrome who were monitored for 27 days. Throughout the period, they were inpatients at FMRP-USPs teaching medical facility (Hospital das Clnicas in Ribeiro Preto).
The day-to-day calorie intake of each participant was identified as a function of their standard metabolic process (energy expense at rest). A standard Western diet of 50% carbohydrates, 20% protein, and 30% fat was served to one group, however it contained 25% less calories.
Protein intake was decreased to 10% in the 2nd group. Each volunteers calorie consumption was matched to their standard energy expense. 4 grams of salt were consumed daily by both groups.
The results revealed that both the calorie and protein limitation groups slimmed down owing to a reduction in body fat and that the symptoms of metabolic syndrome improved. Reduced body fat is known to be related to reduced blood sugar level and more regular levels of lipids and high blood pressure.
” After 27 days of tracking, both groups had similar lead to regards to lower blood glucose, weight loss, controlled high blood pressure, and lower levels of triglycerides and cholesterol. Both diets improved insulin level of sensitivity after treatment. Body fat reduced, as did waist and hip area, however without loss of muscle mass,” said Maria Cristina Foss de Freitas, the last author of the post and a professor at FMRP-USP.
The findings confirmed those of previous studies involving experiments on mice. “Here, however, we succeeded in conducting a fully managed randomized clinical trial lasting 27 days, with an individualized menu developed to satisfy each patients requirements,” Foss de Freitas stated.
Manipulation of dietary macronutrients– fat, carbohydrate, and protein– is adequate to obtain the beneficial impacts of dietary limitation. “We demonstrated that protein constraint lowers body fat while maintaining muscle mass. Thats essential considering that the weight-loss arising from restrictive diets is typically connected with loss of muscle mass,” Ferraz-Bannitz stated.
The research study did not examine the molecular systems that could explain the advantageous effects of protein restriction diets, however the researchers believe low protein consumption set off a change in the metabolic process or improved the organisms energy management by leading it to burn fat in order to produce energy for cells. “We only have hypotheses up until now. One is that molecular paths are triggered to translate the reduction in important amino acids as being a signal to lower food consumption while leading to the production of hormonal agents that usually increase when were fasting,” Mori stated. “Studies in animal designs have actually revealed the participation of such pathways in the effects of both protein and calorie limitation, both of which result in fat loss.”
Despite the appealing results of their research studies, the scientists explain that the diets involved were individualized. Mori likewise worried that they concentrated on a particular population of patients with metabolic syndrome (weight problems, diabetes, hypertension, and irregular levels of cholesterol).
Its also been found that the excessive protein intake common in the standard Western diet can be an issue. We should not forget protein deficiency can lead to extreme health issues, as has been well-described in pregnant women, for example,” he added.
Reference: “Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial” by Rafael Ferraz-Bannitz, Rebeca A. Beraldo, A. Augusto Peluso, Morten Dall, Parizad Babaei, Rayana Cardoso Foglietti, Larissa Marfori Martins, Patricia Moreira Gomes, Julio Sergio Marchini, Vivian Marques Miguel Suen, Luiz C. Conti de Freitas, Luiz Carlos Navegantes, Marco Antônio M. Pretti, Mariana Boroni, Jonas T. Treebak, Marcelo A. Mori, Milton Cesar Foss and Maria Cristina Foss-Freitas, 28 June 2022, Nutrients.DOI: 10.3390/ nu14132670.
The research study was funded by the São Paulo Research Foundation. The research study likewise benefited from a FAPESP Thematic Project on methods for mimicking the effects of dietary constraint, led by Marcelo Mori, a teacher at the State University of Campinas (UNICAMP), also in Brazil.
A multidisciplinary team of researchers performed the study, consisting of scientists affiliated with the University of Copenhagen in Denmark, the University of São Paulo, and the National Cancer Institute (INCA) in Brazil, along with the Obesity and Comorbidities Research Center (OCRC), a Research, Innovation, and Dissemination Center (RIDC) moneyed by FAPESP and hosted by UNICAMP.