This research study is the very first to evaluate the separate mechanisms of caffeine and non-caffeine parts in reducing the intensity of NAFLD, a common problem connected to Type 2 Diabetes.
According to a current research study released in the journal Nutrients by the University of Coimbra, caffeine, polyphenols, and other natural substances in coffee might play a role in decreasing the seriousness of non-alcoholic fatty liver disease (NAFLD) in obese people with type 2 diabetes (T2D).
NAFLD includes a variety of liver conditions brought on by the accumulation of fat in the liver. This can lead to liver fibrosis, which can advance to cirrhosis (liver scarring) and even liver cancer. Unlike other liver conditions, NAFLD is regularly triggered by a sedentary lifestyle and a diet high in calories, instead of alcohol consumption.
Study participants with greater coffee consumption had healthier livers. Subjects with higher caffeine levels were less likely to have liver fibrosis, while greater levels of non-caffeine coffee components were substantially connected with decreased fatty liver index scores. The research study suggests that for obese T2D patients, a higher intake of coffee is related to less severe NAFLD1.
NAFLD includes a range of liver conditions caused by the accumulation of fat in the liver. Subjects with higher caffeine levels were less likely to have liver fibrosis, while higher levels of non-caffeine coffee parts were substantially associated with reduced fatty liver index scores. Caffeine consumption is associated with reduced liver fibrosis in NAFLD and other persistent liver conditions.
Researchers surveyed 156 middle-aged borderline-obese individuals on their coffee consumption, of which 98 topics had T2D, and supplied 24-hour urine samples. This was used to determine caffeine and non-caffeine metabolites– the natural items of the body breaking down coffee. This approach follows a recent shift to examining urine rather than self-reported usage, for more specified, quantitative information on coffee intake1.
Caffeine consumption is related to reduced liver fibrosis in NAFLD and other persistent liver conditions. It has actually been suggested that other coffee elements, consisting of polyphenols, decrease oxidative stress in the liver, in turn decreasing the risk of fibrosis in addition to improving glucose homeostasis in both healthy and obese subjects. All these aspects might likewise relieve the intensity of T2D.
Corresponding author of the research study, John Griffith Jones, PhD., Senior Researcher in the Center for Neuroscience and Cell Biology at the University of Coimbra, Portugal, commented: “Due to changes in modern-day diet and way of life, there is an increase in obesity rates and incidence of both T2D and NAFLD, which can eventually establish into more irreversible and severe conditions, burdening health care systems. Our research is the very first to observe that higher cumulative amounts of both caffeine and non-caffeine metabolites in urine are related to a decreased severity of NAFLD in obese people with T2D.”
Reference: “Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes” by Margarida Coelho, Rita S. Patarrão, Inês Sousa-Lima, Rogério T. Ribeiro, Maria João Meneses, Rita Andrade, Vera M. Mendes, Bruno Manadas, João Filipe Raposo, M. Paula Macedo and John G. Jones, 20 December 2022, Nutrients.DOI: 10.3390/ nu15010004.