June 16, 2024

New Research Links Irritable Bowel Syndrome to Reduced Bacterial Diversity

The scientists discovered that the gut bacterial community is less diverse in IBS clients than in healthy people, stated Shim. Furthermore, the abundance of 21 bacterial species varied between IBS patients and healthy controls. The findings were not statistically considerable in the pediatric associate due to a small sample size.
The private investigators proved that the disrupted gut bacterial community “is connected with IBS, though this does not suggest that the relationship is causal,” stated Shim. “Functional research studies are needed to show whether the modification in gut micro-organisms contributes to the advancement of IBS.”
Despite the fact that IBS is a common condition, its pathogenesis remains unidentified, and yet there is no efficient treatment strategy. “Based on the epidemiological research studies of IBS patients, modified gut microbiota was proposed as one of the possible reasons for IBS,” the scientists compose. “Acute bacterial gastroenteritis can cause chronic, asymptomatic, low-grade digestive tract wall inflammation sufficient to change epithelial and neuromuscular cell function.”
” Gut Bacterial Dysbiosis in Irritable Bowel Syndrome: a Case-Control Study and a Cross-Cohort Analysis Using Publicly Available Data Sets” by Gun-Ha Kim, Kihyun Lee and Jung Ok Shim, 18 January 2023, Microbiology Spectrum.DOI: 10.1128/ spectrum.02125-22.

Irritable Bowel Syndrome (IBS) is a typical food poisoning that impacts the large intestinal tract. It is defined by symptoms such as abdominal pain, bloating, constipation, and diarrhea.
According to a group of Korean scientists, individuals with Irritable Bowel Syndrome (IBS) have a reduced variety of germs in their intestinal tracts compared to healthy individuals. This is the very first research study to develop a clear connection between IBS and a reduction in gut microbiota diversity. The findings were released in the American Society for Microbiologys journal Microbiology Spectrum.
Typically, “More than 10,000 species of bacterium reside in the human intestinal tract,” said corresponding author Jung Ok Shim, M.D., Ph.D., professor of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Korea University College of Medicine, Seoul. Disturbance of the microbiome of the human gastrointestinal tract can trigger IBS. Generally, IBS triggers stomach, diarrhea, and bloating discomfort or cramps.
Previous research studies of gut bacteria in clients with IBS have actually been questionable, with inconsistent outcomes, due to little sample size and lack of consistent analytical methods utilized amongst these research studies, said Shim. The detectives combined their own dataset with 9 published, shared datasets, incorporating 576 IBS patients and 487 healthy controls, evaluating them with a “unified information processing and analytical approach.”

According to a group of Korean researchers, individuals with Irritable Bowel Syndrome (IBS) have actually a decreased variety of bacteria in their intestinal tracts compared to healthy people. The researchers found that the gut bacterial community is less varied in IBS patients than in healthy individuals, stated Shim. “Based on the epidemiological research studies of IBS clients, altered gut microbiota was proposed as one of the possible causes of IBS,” the scientists write.