Healthy dogs and felines may be transmitting multidrug-resistant organisms (MDROs) to their hospitalized owners, while humans might also be passing these microbes to their pets, according to research that will exist at the European Congress of Clinical Microbiology & & Infectious Diseases. The study highlights the potential transmission of antibiotic-resistant germs in between animals and people.
Multi-drug-resistant organisms can be transferred in between healthy canines and cats and their hospitalized owners.
Luckily, just a small number of cases were found suggesting family pets are not a significant source of antibiotic-resistant infections in hospital patients.
Healthy canines and cats might be passing on multidrug-resistant organisms (MDROs; bacteria that resist treatment with more than one antibiotic) to their hospitalized owners, and likewise, people might be transferring these harmful microbes to their animals, according to new research existing at this years European Congress of Clinical Microbiology & & Infectious Diseases (ECCMID) in Copenhagen, Denmark (April 15-18).
The study of over 2,800 healthcare facility patients and their companion animals is by Dr. Carolin Hackmann from Charité University Hospital Berlin, Germany, and colleagues.
” Our findings verify that the sharing of multidrug-resistant organisms between companion animals and their owners is possible,” says Dr. Hackmann. “However, we identified only a handful of cases suggesting that neither feline nor dog ownership is an important risk element for multidrug-resistant organism colonization in healthcare facility clients.”
The role of animals as prospective tanks of MDROs is a growing concern worldwide. Antimicrobial resistance occurs when infection-causing microorganisms (such as infections, germs, or fungi) evolve to end up being resistant to the drug developed to kill them. Estimates recommend that antimicrobial-resistant infections caused almost 1.3 million deaths and were associated with almost 5 million deaths worldwide in 2019. [1]
In this case control research study, scientists wanted to learn whether animals (ie, pets and cats) contribute in the infection of healthcare facility patients with MDROs.
They concentrated on the most typical superbugs in health center clients– methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), 3rd generation cephalosporin-resistant Enterobacterales (3GCRE) and carbapenem-resistant Enterobacterales (CRE), which are resistant to multiple prescription antibiotics including penicillin and cephalosporins.
In between June 2019 and September 2022, nasal and rectal swabs were gathered from 2,891 clients hospitalized in Charité University Hospital Berlin (1,184 patients with previous colonization or colonization on admission and 1,707 recently confessed clients as controls), and from any pets and cats that lived in their homes.
Hereditary sequencing was used to recognize both the species of germs in each sample, and the presence of drug-resistance genes. Whole genome sequencing was utilized to validate the possible sharing of resistant bacteria.
Participants were likewise asked about widely known risk aspects for MDROs (e.g., current MDRO infections or usage of prescription antibiotics, recent health center stays, existence of main or urinary venous catheters), along with info about the variety of family pets in the household, the closeness of contact, and pet health.
In general, 30% (871/2,891) of healthcare facility patients evaluated favorable for MDROs, and 70% (2,020/ 2,891) evaluated negative. The rate of pet dog ownership was 11% (93/871) and feline ownership 9% (80/871) in those who evaluated MDRO-positive, and 13% (267/2,020 and 253/2,020 respectively) in MDRO-negatives.
All 626 animal owners were asked to send out throat and stool swab samples of their family pets. In general, 300 pet owners returned samples from 400 pets. Of these samples, 15% (30/203) of pet dogs and 5% (9/197) of cats tested positive for at least one MDRO. In four cases, MDROs were phenotypically coordinating (MDROs were the same types and revealed the same antibiotic resistance) between pets and their owners.
Entire genome sequencing validated that only one of the matching sets was genetically identical in a pet and its owner. The matching pathogen was 3GCR Escherichia coli (common in the intestines of healthy people and animals).
” Although the level of sharing between healthcare facility patients and their family pets in our research study is extremely low, carriers can shed bacteria into their environment for months, and they can be a source of infection for other more vulnerable people in the medical facility such as those with a weak immune system and the old or extremely young,” states Dr. Hackmann.
This is an observational research study and can not show that close contact with pets triggers colonization with MDROs, but only suggest the possibility of co-carriage, while the direction of transfer is uncertain. The authors indicate numerous constraints, including a possible under-reporting of MDRO colonization in pets due to issues in taking swab samples, which was done by the animal owners themselves. Finally, the study results apply to the setting of hospital patients in a city location and therefore might not apply to the general population or MDRO high-risk groups like livestock farmers.
Referral:
The role of animals as potential reservoirs of MDROs is a growing concern worldwide. All 626 family pet owners were asked to send throat and stool swab samples of their family pets. In general, 300 animal owners sent back samples from 400 animals. In four cases, MDROs were phenotypically coordinating (MDROs were the same types and showed the same antibiotic resistance) in between family pets and their owners.
The authors point to several constraints, including a possible under-reporting of MDRO colonization in family pets due to issues in taking swab samples, which was done by the pet owners themselves.
Fulfilling: European Society of Clinical Microbiology and Infectious Diseases (ECCMID) 2023.
” Global concern of bacterial antimicrobial resistance in 2019: a methodical analysis” by Antimicrobial Resistance Collaborators, 19 January 2022, The Lancet.DOI: 10.1016/ S0140-6736( 21 )02724-0.
