” Because of our innovative approach of assessing cognitive results using internet-based tests, we were able to analyze the results of a multivitamin in thousands of research study individuals. The findings are appealing and certainly set the phase for essential follow-up research studies about the impact of multivitamin supplements on cognition,” stated Adam Brickman, PhD, who co-led the COSMOS-Web study with Lok-Kin Yeung, PhD, at Columbia University.
In a research study released on May 24 in The American Journal of Clinical Nutrition, researchers from the Brigham and their partners at Columbia University report from COSMOS-Web that daily multivitamin supplements, compared to placebo, improved memory amongst participants. The study is the second from COSMOS, along with the formerly released COSMOS-Mind, to discover an enhancement in memory function among those taking a multivitamin.
” The findings that a day-to-day multivitamin improved memory and slowed cognitive decrease in 2 different research studies in the COSMOS randomized trial is remarkable, suggesting that multivitamin supplements holds promise as a safe, accessible, and cost effective method to protecting cognitive health in older grownups,” said co-author JoAnn Manson, MD, chief of the Brighams Division of Preventive Medicine. Manson is a co-leader of the parent COSMOS trial with Howard Sesso, ScD, associate director of the Brighams Division of Preventive Medicine.
Sesso includes, “With these 2 research studies on cognition in hand for COSMOS, and more to come in COSMOS, it is important to comprehend how an everyday multivitamin may safeguard against memory loss and cognitive decrease, and whether specific subgroups based on dietary status or other aspects might benefit more, or less.”
Compared to the placebo group, individuals randomized to multivitamin supplements did significantly better on the memory tests at the prespecified primary time point of 1 year, with advantages sustained throughout the 3 years of follow-up. The scientists estimated that the multivitamin intervention enhanced memory efficiency by the equivalent of 3.1 years compared to the placebo group.
” Because of our innovative approach of evaluating cognitive outcomes using internet-based tests, we were able to examine the impacts of a multivitamin in thousands of research study participants. The findings are promising and definitely set the stage for important follow-up studies about the effect of multivitamin supplements on cognition,” said Adam Brickman, PhD, who co-led the COSMOS-Web research study with Lok-Kin Yeung, PhD, at Columbia University.
Outcomes from COSMOS-Web, conducted as a cooperation in between the Brigham and Columbia University, supply verification of earlier findings from COSMOS-Mind connecting day-to-day multivitamins to slowing of cognitive decrease. COSMOS-Mind, which was performed as a cooperation between the Brigham and Wake Forest School of Medicine, had actually tested 2,200 older adults for 3 years and revealed that randomized task to a daily multivitamin supplement was related to a 60% slowing of international cognitive aging compared to placebo, equivalent to 1.8 years decrease in cognitive decrease (study was funded by the National Institute on Aging and released in Alzheimers and Dementia in September 2022).
The authors note that the COSMOS-Web study provides proof that multivitamin supplementation has cognitive advantages however additional research study will be needed to identify the particular nutrients contributing the most to this benefit and the hidden mechanisms included. Extra research is likewise needed to identify whether the findings are generalizable to a more varied research study population with lower instructional levels and lower socioeconomic status.
For more on this research study, see Major Study Finds Daily Multivitamin Improves Memory in Older Adults.
Referral: “Multivitamin supplementation enhances memory in older adults: A randomized clinical trial” by Lok-Kin Yeung, Daniel M. Alschuler, Melanie Wall, Heike Luttmann-Gibson, Trisha Copeland, Christiane Hale, Richard P. Sloan, Howard D. Sesso, JoAnn E. Manson and Adam M. Brickman, 24 May 2023, American Journal of Clinical Nutrition.DOI: 10.1016/ j.ajcnut.2023.05.011.
Authors: Lok-Kin Yeung (Columbia), Daniel M. Alschuler (New York State Psychiatric Institute), Melanie Wall (Columbia), Heike Luttman-Gibson (Brigham and Womens Hospital/Harvard), Trisha Copeland (Brigham and Womens/ Harvard), Richard P. Sloan (Columbia), Howard D. Sesso (Brigham and Womens/ Harvard), JoAnn E. Manson (Brigham and Womens/ Harvard) and Adam M. Brickman (Columbia).
Disclosures: Sesso furthermore reported receiving investigator-initiated grants from Pure Encapsulations and Pfizer Inc. and honoraria and/or travel for lectures from the Council for Responsible Nutrition, BASF, NIH, and the American Society of Nutrition during the conduct of the study.
Financing: COSMOS-Web was supported by investigator-initiated grants from Mars Edge, a section of Mars Inc. and the National Institutes of Health (AG050657, HL157665, ag071611, and ey025623). Multivitamin and placebo tablets and packaging were donated by Pfizer, Inc Consumer Healthcare (now Haleon).
The research study, COSMOS-Web, included over 3,500 individuals aged 60 and older who took either multivitamins or a placebo and underwent annual cognitive assessments for three years. These findings support those from another COSMOS research study, COSMOS-Mind, which associated daily multivitamin supplements with a 60% slowing of global cognitive aging.
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS), a massive across the country randomized trial directed by researchers at Brigham and Womens Hospital (BWH), an establishing member of Mass General Brigham, consisted of two separate medical trials (COSMOS-Web and COSMOS-Mind) screening multivitamin supplements on modifications in cognitive function.
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS), a nation-wide randomized trial led by scientists from Brigham and Womens Hospital and Columbia University, has actually found that daily multivitamin supplements enhance memory and slow cognitive decline in older adults
2nd major research study from COSMOS finds that participants randomized to get an everyday multivitamin supplement showed improvements in memory compared to placebo.
The study, COSMOS-Web, included over 3,500 participants aged 60 and older who took either multivitamins or a placebo and went through annual cognitive evaluations for 3 years. The multivitamin group showed considerable memory improvement comparable to a 3.1 year turnaround of cognitive aging compared to the placebo group, with the biggest advantages observed in participants with a history of cardiovascular illness. These findings corroborate those from another COSMOS study, COSMOS-Mind, which associated daily multivitamin supplementation with a 60% slowing down of global cognitive aging.
Randomized scientific trials have actually revealed couple of efficient techniques to enhance memory or slow cognitive decline amongst older grownups. Nutritional interventions may play a crucial function since the brain requires numerous nutrients for optimal health, and shortages in one or more of these nutrients might accelerate cognitive decline. The COcoa Supplement and Multivitamin Outcomes Study (COSMOS), a large-scale across the country randomized trial directed by researchers at Brigham and Womens Hospital (BWH), an establishing member of Mass General Brigham, consisted of two different medical trials (COSMOS-Web and COSMOS-Mind) screening multivitamin supplements on modifications in cognitive function.
