In a study just recently released in eBioMedicine, Elias and his associates turned stem cells into ovarian cells, which enabled mice with chemo-induced infertility to produce babies.2 The scientists method relied on induced pluripotent stem cells (iPSCs)– cells that are rewound in the laboratory into a precursor state capable of turning into many different types of cells. Effective distinction of steroidogenic and germ-like cells from epigenetically-related iPSCs obtained from ovarian granulosa cells. Recovery of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced premature ovarian failure in mice.
In a study recently published in eBioMedicine, Elias and his colleagues turned stem cells into ovarian cells, which permitted mice with chemo-induced infertility to produce infants.2 The researchers approach relied on induced pluripotent stem cells (iPSCs)– cells that are rewound in the laboratory into a precursor state capable of turning into numerous various types of cells. As an extra surprise, Elias understood that some of the mice puppies had actually grown from stem cell-derived eggs while others had actually grown from eggs that the mother made herself– something that had been difficult simply a few months earlier.Eliass theory is that as the stem cell-derived ovarian cells take root in the ovaries, they produce an essential hormone called anti-Müllerian hormonal agent, which declined in the mice after receiving chemotherapy. Efficient differentiation of germ-like and steroidogenic cells from epigenetically-related iPSCs obtained from ovarian granulosa cells. Healing of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced early ovarian failure in mice. Generation of ovarian hair follicles from mouse pluripotent stem cells.
