May 7, 2024

Sugarcane Secrets: Scientists Discover Potential Cause of Mystery Kidney Disease in Agricultural Workers

Burning sugarcane and rice husks may release toxins connected to persistent kidney illness in farm employees, according to a current research study. This includes to known aspects like environment modification, advising a reevaluation of agricultural burning practices.
Scientists from CU Anschutz teamed up with physicians in El Salvador and discovered raised concentrations of silica nanoparticles in the kidney tissues of clients with a strange illness.
According to a current research study published in the American Journal of Kidney Diseases, the combustion of sugarcane and rice husks may be launching a toxicant causing a strange kidney illness in agricultural laborers.
A continuous epidemic of chronic kidney disease has been observed among manual workers in hot agricultural neighborhoods throughout the world, including along the Pacific coast of Central America, India, and Sri Lanka. While heat tension and climate modification have contributed to this epidemic, researchers have actually determined tiny silica particles launched from sugarcane ash that can be inhaled or ingested through infected drinking water that causes chronic kidney damage.
” To date, there are no studies we understand that have determined a toxicant that can cause chronic kidney illness which is actually present in kidney tissues of patients experiencing this unidentified illness,” says Jared Brown, PhD, professor at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences and among the senior authors. “These information provide an essential clue to the secret and recommend that in addition to heat stress from environment modification that toxicants from sugarcane ash might be adding to the disease.”

The authors discovered significantly more silica particles in the kidney tissue of patients with this particular illness compared to clients with other known kidney illness. “This disease is recognized as one of the very first recently acknowledged diseases resulting particularly from a warming environment. Ideally, this work will spur efforts to focus on sugarcane burning as a potential risk factor for the advancement of this mystical kidney illness in workers and people who live surrounding to sugarcane fields.”

Research study Findings and Implications
University of Colorado Anschutz Medical Campus worked with physicians at Hospital Rosales in San Salvador, El Salvador to assess patients suffering from this strange persistent kidney illness. The authors discovered considerably more silica particles in the kidney tissue of patients with this specific illness compared to patients with other recognized kidney diseases.
“This illness is recognized as one of the very first freshly recognized diseases resulting particularly from a warming climate. Ideally, this work will spur efforts to focus on sugarcane burning as a prospective danger element for the development of this strange kidney disease in individuals and workers who live adjacent to sugarcane fields.”
Reference: “Silica Nanoparticles and Mesoamerican Nephropathy: A Case Series” by Keegan L. Rogers, Carlos A. Roncal-Jimenez, Ricardo Leiva, Arthur Stem, Julia Wijkstrom, Lissbeth Serpas, Marvin A. González-Quiroz, Fumihiko Sasai, Annika Wernerson, Joshua Schaeffer, Jacob Fox, Matthew Ray, Anip Bansal, Manuel Urra, Jaime Butler-Dawson, Scott Lucia, Lee S. Newman, Jason Glaser, Richard J. Johnson and Jared M. Brown, 23 October 2023, American Journal of Kidney Diseases.DOI: 10.1053/ j.ajkd.2023.06.010.