Recent research study suggests that the CD300f immune receptor substantially affects mices life-span and aging procedure, with its lack causing early aging symptoms and cognitive decrease, especially in women. This discovery opens brand-new opportunities for comprehending aging and Alzheimers disease, highlighting the importance of body immune system modifications in these processes.
Recent research published in the journal Cell Reports reveals that life span and healthy aging in mice can be considerably affected by a particular protein found in specific immune system cells. This protein, called the CD300f immune receptor, plays a crucial role in figuring out the life-span and health of these animals. The research study likewise suggests that the absence of CD300f is connected to reduced life expectancy and early beginning of cognitive decline and aging-related pathologies, with an especially greater influence on women.
” Our research study suggests that changes in body immune system cells, for instance, in microglia and macrophages, can determine the healthy aging degree in mice,” keeps in mind Hugo Peluffo, leader of this study and member of the Faculty of Medicine and Health Sciences and the Institute of Neurosciences (UBneuro) of the University of Barcelona.
Understanding how the CD300f immune receptor– and the myeloid cells of the immune system– can identify by themselves the onset rate of aging-associated pathologies, “will help to much better understand this process, and it will add to the design of methods to control its action. Using the immune receptor CD300f as a target in biomedicine,” notes the professional. “Also, our group has actually formerly shown that some variations of the CD300f immune receptor might be beneficial as biomarkers in clients.”
Recent research published in the journal Cell Reports exposes that life span and healthy aging in mice can be significantly affected by a particular protein discovered in certain immune system cells. Comprehending how the CD300f immune receptor– and the myeloid cells of the immune system– can determine by themselves the start rate of aging-associated pathologies, “will assist to better comprehend this process, and it will contribute to the style of strategies to manage its action. “Also, our group has previously shown that some variations of the CD300f immune receptor could be useful as biomarkers in clients.”
The paper, whose first author is the specialist Frances Evans (Institute Pasteur and Udelar), consists of the involvement of groups from the Molecular Imaging Uruguayan Center (CUDIM), to name a few institutions.
What role does this receptor play in the procedure of aging?
The CD300f receptor is a protein expressed by body immune system cells that regulates cell metabolism and swelling. This study exposes the first evidence of its role at the same times related to aging and senescence.
” In particular, we discovered that mice that did not have the CD300f immune receptor established too soon some pathologies connected with aging (cognitive deficits, motor incoordination, tumors, etc) and even damage in a number of organs such as the brain, the liver or the lungs. We observed a crucial effect on females, the most afflicted ones,” states Hugo Peluffo.
The research study is based upon a detailed tracking of several friends of animals for thirty months, a methodological development that allowed the scientists to see the procedure of real aging in these animals without using sped up aging designs, which do not fully represent a process that always includes the gradual accumulation of modifications with age.
Immune receptors and Alzheimers illness
The scientist explains that “the aim is to keep studying the effects of the dysfunction of the CD300f immune receptor on brain aging, in specific on microglia.”
In these lines, a project led by Professor Hugo Peluffo to study the relationship between aging and Alzheimers illness has just received one of the Alzheimers research study grants from the Pasqual Maragall Foundation. It will explore how immune cells in the worried system, known as microglia, affect the aging process and the late beginning of Alzheimers. “In this project, funded by the Pasqual Maragall Foundation, we will study the potential role of this immune receptor in Alzheimers disease,” says the researcher.
Reference: “CD300f immune receptor adds to healthy aging by regulating inflammaging, metabolism, and cognitive decline” by Frances Evans, Daniela Alí-Ruiz, Natalia Rego, María Luciana Negro-Demontel, Natalia Lago, Fabio Andrés Cawen, Bruno Pannunzio, Paula Sanchez-Molina, Laura Reyes, Andrea Paolino, Jorge Rodríguez-Duarte, Valentina Pérez-Torrado, Almudena Chicote-González, Celia Quijano, Inés Marmisolle, Ana Paula Mulet, Geraldine Schlapp, María Noel Meikle, Mariana Bresque, Martina Crispo, Eduardo Savio, Cristina Malagelada, Carlos Escande and Hugo Peluffo, 20 October 2023, Cell Reports.DOI: 10.1016/ j.celrep.2023.113269.
It will check out how immune cells in the anxious system, understood as microglia, influence the aging process and the late beginning of Alzheimers.
