New research highlights the anti-aging benefits of vitamin D and its receptor in Drosophila, exposing their considerable role in stem cell health and longevity, and offering insights into aging mechanisms.Adult stem cells play an important function in keeping tissue balance, with their diminished functionality connected to aging and associated health problems, impacted by the surrounding cells environment. Scientific research studies in human beings have regularly revealed a decline in vitamin D and its receptor levels due to aging and cancer. Regardless of this, the methods which the vitamin D/vitamin D receptor (VitD/VDR) pathway aids in anti-aging and life expectancy extension remain unclear.In a brand-new research study, researchers Joung-Sun Park, Hyun-Jin Na, and Yung-Jin Kim from Pusan National University and Korea Food Research Institute aimed to figure out the protective role of the vitamin D/vitamin D receptor path in distinguished enterocytes (ECs) throughout intestinal stem cell (ISC) aging.Inhibitory result of VitD on age- and oxidative stress-related build-up of supernumerary centrosomes in midgut ISCs. Credit: 2024 Park et al.Study Objective and MethodologyThe scientists specified, “This study intended to identify the protective function of VitD/VDR in separated ECs throughout ISC aging using the adult Drosophila intestine design.” By using a reputable Drosophila midgut model for stem cell aging biology, the researchers revealed that vitamin D receptor knockdown in ECs caused ISC proliferation, EC death, ISC aging, and enteroendocrine cell distinction. In addition, age- and oxidative stress-induced boosts in ISC expansion and centrosome amplification were reduced by vitamin D treatment. In conclusion, this study provides direct evidence of the anti-aging role of the VitD/VDR path, involving protecting ECs throughout aging, and offers valuable insights for checking out the molecular mechanisms underlying enhanced healthy aging in Drosophila.” Our findings recommend a direct proof of the anti-aging function of the vitamin D/vitamin D receptor pathway and offer insights into the molecular mechanisms underlying healthy aging in Drosophila.” Reference: “The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut” by Joung-Sun Park, Hyun-Jin Na and Yung-Jin Kim, 7 February 2024, Aging.DOI: 10.18632/ aging.205518.
