The lead and senior authors Michael Molitor and Philip Wenzel commented: “We learned from our studies that airplane noise exposure before MI substantially magnifies subsequent cardiovascular inflammation and intensifies ischemic heart failure helped with by pro-inflammatory vascular conditioning. Our translational results show that human beings that had noise exposure in the past will have a worse outcome if they have an acute MI later in life”.
The cardiologist and noise professional Thomas Münzel concluded: “This is the first time that a translational study was carried out to investigate the effects of aircraft sound on severe myocardial infarction. In experimental animals and humans, airplane noise markedly exaggerated the effects of ischemia (left ventricular function, swelling, and oxidative tension) in action to an intense myocardial infarction.
Reference: “Aircraft sound exposure induces pro-inflammatory vascular conditioning and enhances vascular dysfunction and impairment of heart function after myocardial infarction” by Michael Molitor, Maria T Bayo-Jimenez, Omar Hahad, Claudius Witzler, Stefanie Finger, Venkata S Garlapati, Sanela Rajlic, Tanja Knopp, Tabea K Bieler, Melania Aluia, Johannes Wild, Jeremy Lagrange, Recha Blessing, Steffen Rapp, Andreas Schulz, Hartmut Kleinert, Susanne Karbach, Sebastian Steven, Wolfram Ruf, Philipp Wild, Andreas Daiber, Thomas Münzel and Philip Wenzel, 26 January 2023, Cardiovascular Research.DOI: 10.1093/ cvr/cvad021.
The research study was moneyed by the Boehringer Ingelheim Foundation.
Myocardial infarction, likewise called a cardiovascular disease, happens when the blood supply to a part of the heart muscle is obstructed, causing damage to the heart muscle.
New research indicates that aircraft sound intensifies the damage brought on by myocardial infarction.
Traffic sound might be a significant aspect in the development and worsening of ischemic heart illness. A recent discovery by researchers from the Cardiology Department at the University Medical Center Mainz found that exposure to sound (with an average sound pressure level of 72 dB and a peak level of 85 dB) for approximately 4 days led to increased pro-inflammatory aortic gene expression in mice.
The scientists discovered that sound caused adhesion and seepage of inflammatory cells in the cardiac and vascular tissue. This was accompanied by an increased percentage of leukocytes with a pro-inflammatory, reactive oxygen species (ROS)- producing phenotype and expression of the phagocytic NADPH oxidase/phospho-NF κB in peripheral blood. In order to cause myocardial infarction and get worse cardiac function, the group used the long-term LAD ligation design.
Noise-induced tension causes the release of stress hormonal agents that activate an inflammatory reaction, resulting in more serious myocardial infarction, oxidative stress and endothelial dysfunction, and subsequent heart failure. Credit: Cardiovascular Research
Sound direct exposure prior to MI caused more extreme endothelial dysfunction and more noticable increases in vascular ROS and indications of swelling in animals preconditioned with sound. Participants of the population-based Gutenberg Health Cohort Study (median follow-up:11.4 y) with incident MI revealed raised C-reactive protein (CRP) at standard and worse LVEF after MI in case of a history of sound direct exposure and subsequent development of noise inconvenience.
The researchers found that sound triggered adhesion and seepage of inflammatory cells in the vascular and heart tissue. The cardiologist and noise expert Thomas Münzel concluded: “This is the first time that a translational research study was performed to investigate the results of airplane sound on severe myocardial infarction. In experimental animals and people, airplane sound markedly exaggerated the repercussions of ischemia (left ventricular function, swelling, and oxidative stress) in response to an intense myocardial infarction.