” We make the case that Alzheimers disease is driven by diet,” stated the research studys lead author Richard Johnson, MD, professor at the University of Colorado School of Medicine specializing in renal illness and high blood pressure. The study co-authors consist of Maria Nagel, MD, research professor of neurology at the CU School of Medicine.
Johnson and his group recommend that advertisement is a harmful adaptation of an evolutionary survival path utilized in animals and our far-off ancestors during times of shortage.
” A fundamental tenet of life is to assure sufficient food, water, and oxygen for survival,” the research study said. “Much attention has actually focused on the intense survival responses to hypoxia and hunger. Nature has actually established a clever method to safeguard animals before the crisis in fact happens.”
Foraging is just efficient if metabolism is prevented in different parts of the brain. Fructose, a kind of sugar, helps damp down these centers, allowing more focus on food event.
In fact, the researchers discovered the entire foraging response was set in movement by the metabolism of fructose whether it was eaten or produced in the body. Metabolizing fructose and its by-product, intracellular uric acid, was vital to the survival of both humans and animals.
The scientists noted that fructose decreases blood flow to the brains cortex included in self-control, in addition to the hippocampus and thalamus. Blood flow increased around the visual cortex associated with food reward. All of this stimulated the foraging action.
” We believe that initially the fructose-dependent reduction in cerebral metabolic process in these areas was reversible and suggested to be useful,” Johnson said. “But relentless and chronic decrease in cerebral metabolic process driven by frequent fructose metabolic process leads to progressive brain atrophy and nerve cell loss with all of the functions of advertisement.”
Johnson thinks the survival action, what he calls the survival switch, that helped ancient people survive durations of deficiency, is now stuck in the on position in a time of relative abundance. This leads to the overeating of high-fat, sugary and salted food prompting excess fructose production.
Fructose produced in the brain can result in swelling and ultimately Alzheimers illness, the research study stated. Animals given fructose show memory lapses, a loss in the capability to navigate a maze, and inflammation of the nerve cells.
” A research study found that if you keep lab rats on fructose enough time they get tau and amyloid beta proteins in the brain, the exact same proteins seen in Alzheimers illness,” Johnson stated. “You can find high fructose levels in the brains of individuals with Alzheimers as well.”
Johnson thinks that the tendency of some advertisement clients to stray might be a vestige of the ancient foraging action.
The research study stated more research is required on the role of fructose and uric acid metabolic process in advertisement.
” We suggest that both pharmacologic and dietary trials to minimize fructose direct exposure or block fructose metabolic process must be carried out to identify if there is potential advantage in the prevention, management or treatment of this illness,” Johnson said.
Recommendation: “Could Alzheimers illness be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?” by Richard J. Johnson, Dean R. Tolan, Dale Bredesen, Maria Nagel, Laura G. Sánchez-Lozada, Mehdi Fini, Scott Burtis, Miguel A. Lanaspa and David Perlmutter, 11 January 2023, American Journal of Clinical Nutrition.DOI: 10.1016/ j.ajcnut.2023.01.002.
The research studys co-authors consist of Dean R. Tolan, Dale Bredesen, Laura G. Sanchez-Lozada, Mehdi Fini, Scott Burtis, Miguel A. Lanaspa and David Pearlmutter.
When threatened with the possibility of starvation, early human beings established a survival reaction that sent them foraging for food. Foraging is just reliable if metabolism is hindered in numerous parts of the brain. Fructose, a kind of sugar, assists damp down these centers, enabling more focus on food event.
The researchers noted that fructose decreases blood circulation to the brains cerebral cortex involved in self-control, as well as the hippocampus and thalamus. All of this promoted the foraging reaction.
According to brand-new research study, ideas to the development and possible treatment of Alzheimers illness might come from an ancient human foraging instinct, sustained by fructose production in the brain.
Scientists state an evolutionary foraging instinct that depended on the sugar fructose, may now be fueling the development of Alzheimers disease.
An ancient human foraging impulse, sustained by fructose production in the brain, might hold clues to the advancement and possible treatment of Alzheimers disease (AD). This is according to researchers at the University of Colorado Anschutz Medical Campus.
Released just recently in The American Journal of Clinical Nutrition, the research study provides a new method of taking a look at a deadly illness defined by unusual accumulations of proteins in the brain that slowly wear down memory and cognition.